Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2.

@article{Saxton1999MorphogeneticMA,
  title={Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2.},
  author={Tracy M. Saxton and Tony J. Pawson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 7},
  pages={3790-5}
}
The SH2 domain-containing tyrosine phosphatase Shp2 plays a pivotal role during the gastrulation of vertebrate embryos. However, because of the complex phenotype observed in mouse mutant embryos, the precise role of Shp2 during development is unclear. To define the specific functions of this phosphatase, Shp2 homozygous mutant embryonic stem cells bearing the Rosa-26 LacZ transgene were isolated and used to perform a chimeric analysis. Here, we show that Shp2 mutant cells amass in the tail bud… CONTINUE READING
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