Morphogenetic and Cellular Movements that Shape the Mouse Cerebellum Insights from Genetic Fate Mapping

@article{Sgaier2005MorphogeneticAC,
  title={Morphogenetic and Cellular Movements that Shape the Mouse Cerebellum Insights from Genetic Fate Mapping},
  author={Sema K. Sgaier and Sandrine Millet and Melissa P. Villanueva and Frada Berenshteyn and Christian E. Song and Alexandra L. Joyner},
  journal={Neuron},
  year={2005},
  volume={45},
  pages={27-40}
}
We used the cerebellum as a model to study the morphogenetic and cellular processes underlying the formation of elaborate brain structures from a simple neural tube, using an inducible genetic fate mapping approach in mouse. We demonstrate how a 90 degrees rotation between embryonic days 9 and 12 converts the rostral-caudal axis of dorsal rhombomere 1 into the medial-lateral axis of the wing-like bilateral cerebellar primordium. With the appropriate use of promoters, we marked specific medial… CONTINUE READING