Morphogenetic Cell Movements: Diversity from Modular Mechanical Properties

@article{Montell2008MorphogeneticCM,
  title={Morphogenetic Cell Movements: Diversity from Modular Mechanical Properties},
  author={Denise J. Montell},
  journal={Science},
  year={2008},
  volume={322},
  pages={1502 - 1505}
}
  • D. Montell
  • Published 5 December 2008
  • Biology, Medicine
  • Science
Animal tissue and organ development requires the orchestration of cell movements, including those of interconnected cell groups, termed collective cell movements. Such movements are incredibly diverse. Recent work suggests that two core cellular properties, cell-cell adhesion and contractility, can largely determine geometry, packing, sorting, and rearrangement of epithelial cell layers. Two additional force-generating properties, the ability to generate cell protrusions and cell adhesion to… Expand
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References

SHOWING 1-10 OF 47 REFERENCES
Gastrulation movements: the logic and the nuts and bolts.
  • M. Leptin
  • Biology, Medicine
  • Developmental cell
  • 2005
TLDR
This work has shown that similarities among different species in patterning and cell biological mechanisms are beginning to allow us to recognize general, conserved principles and speculate on possible ancestral mechanisms of gastrulation. Expand
Compartmentalized morphogenesis in epithelia: From cell to tissue shape
  • F. Pilot, T. Lecuit
  • Biology, Medicine
  • Developmental dynamics : an official publication of the American Association of Anatomists
  • 2005
TLDR
Moving from apical to basal, a review of compartmentalized cellular rearrangements underlying tissue remodeling in Drosophila and compare them with those found in other organisms is reviewed. Expand
folded gastrulation, cell shape change and the control of myosin localization
TLDR
The analysis of fog function provides a direct link from patterning to cell shape change, and shows that secretion of Fog protein is apically polarized, making this the earliest polarized component of a pathway that ultimately drives myosin to the apical side of the cell. Expand
Physical modeling of cell geometric order in an epithelial tissue
TLDR
The model predicts adhesion strengths in the eye epithelium, quantifies their role relative to membrane elasticity, and reveals how simple minimization of interfacial energy can give rise to complex geometric patterns of important biological functionality. Expand
Tracheal branching morphogenesis in Drosophila: new insights into cell behaviour and organ architecture
TLDR
The similarities and differences between flies and vertebrates in branched organ formation that are becoming apparent are discussed, and the use of high resolution in vivo imaging approaches are reviewed. Expand
The Influence of Cell Mechanics, Cell-Cell Interactions, and Proliferation on Epithelial Packing
TLDR
A vertex model is used for the epithelial junctional network in which cell packing geometries correspond to stable and stationary network configurations and accounts qualitatively and quantitatively for the observed packing geometry in the wing disc and its response to perturbation by laser ablation. Expand
Tensile forces govern germ-layer organization in zebrafish
TLDR
It is shown that differential actomyosin-dependent cell-cortex tension, regulated by Nodal/TGFβ-signalling (transforming growth factor β), constitutes a key factor that directs progenitor-cell sorting in germ-layer organization during gastrulation. Expand
Regulation of Cell Adhesion and Collective Cell Migration by Hindsight and Its Human Homolog RREB1
TLDR
It is proposed that HNT and RREB1 are essential to reduce cell-cell adhesion when epithelial cells within an interconnected group undergo dynamic changes in cell shape, also known as collective cell migrations. Expand
Multicellular rosette formation links planar cell polarity to tissue morphogenesis.
TLDR
It is proposed that the generation of higher-order rosette structures links local cell interactions to global tissue reorganization during morphogenesis. Expand
Patterning Mechanisms of Branched Organs
TLDR
This work has shown that different cell and tissue types use a remarkably conserved set of tools to undergo branching morphogenesis, and shed important light on the basis of molecular conservation in the formation of branched structures in diverse organs. Expand
...
1
2
3
4
5
...