Morphogenetic Cell Movements: Diversity from Modular Mechanical Properties

  title={Morphogenetic Cell Movements: Diversity from Modular Mechanical Properties},
  author={Denise J. Montell},
  pages={1502 - 1505}
Animal tissue and organ development requires the orchestration of cell movements, including those of interconnected cell groups, termed collective cell movements. Such movements are incredibly diverse. Recent work suggests that two core cellular properties, cell-cell adhesion and contractility, can largely determine geometry, packing, sorting, and rearrangement of epithelial cell layers. Two additional force-generating properties, the ability to generate cell protrusions and cell adhesion to… 

Force generation, transmission, and integration during cell and tissue morphogenesis.

A new era is opening that emphasizes the similarities of and allows comparisons between distant dynamic biological phenomena because they rely on core machineries that control universal features of cytomechanics.

Collective cell migration in morphogenesis, regeneration and cancer

Comparing different types of collective migration at the molecular and cellular level reveals a common mechanistic theme between developmental and cancer research.

Tension and epithelial morphogenesis in Drosophila early embryos.

Intercellular mechanotransduction during multicellular morphodynamics

Different modes by which mechanical forces are transduced in a multicellular context are described: indirect mechanosensing through compliant substratum, cytoskeletal ‘tug-of-war’ between cell–matrix and cell–cell adhesions, cortical contractility contributing to line tension, and forces mediating collective migration.

Mechanics and regulation of cell shape during the cell cycle.

This chapter provides an overview of the current knowledge on the control of cell morphology, both in terms of general cell mechanics and specifically during the cell cycle, which is important for tissue morphogenesis in a number of developmental contexts.

Unit operations of tissue development: epithelial folding.

The signaling, patterning, and biomechanical transformations that occur in two well-studied model systems of epithelial folding are reviewed to illustrate both the complexity and modularity of tissue development.

Biology and Physics of Cell Shape Changes in Development

Group choreography: mechanisms orchestrating the collective movement of border cells

An overview of the molecular choreography of border cells of the Drosophila melanogaster ovary is provided and its more general implications are provided.

The mechanotransduction machinery at work at adherens junctions.

It is shown that α-catenin is the core mechanosensor that allows cells to locally sense, transduce and adapt to environmental mechanical constrains.

The Role of Cell-Cell Adhesion in the Formation of Multicellular Sprouts.

It is argued that preferential attraction to the surfaces of elongated cells can provide a generic mechanism, shared by several cell types, for multicellular sprout formation.



Compartmentalized morphogenesis in epithelia: From cell to tissue shape

  • F. PilotT. Lecuit
  • Biology
    Developmental dynamics : an official publication of the American Association of Anatomists
  • 2005
Moving from apical to basal, a review of compartmentalized cellular rearrangements underlying tissue remodeling in Drosophila and compare them with those found in other organisms is reviewed.

folded gastrulation, cell shape change and the control of myosin localization

The analysis of fog function provides a direct link from patterning to cell shape change, and shows that secretion of Fog protein is apically polarized, making this the earliest polarized component of a pathway that ultimately drives myosin to the apical side of the cell.

Physical modeling of cell geometric order in an epithelial tissue

The model predicts adhesion strengths in the eye epithelium, quantifies their role relative to membrane elasticity, and reveals how simple minimization of interfacial energy can give rise to complex geometric patterns of important biological functionality.

Tracheal branching morphogenesis in Drosophila: new insights into cell behaviour and organ architecture

The similarities and differences between flies and vertebrates in branched organ formation that are becoming apparent are discussed, and the use of high resolution in vivo imaging approaches are reviewed.

Tensile forces govern germ-layer organization in zebrafish

It is shown that differential actomyosin-dependent cell-cortex tension, regulated by Nodal/TGFβ-signalling (transforming growth factor β), constitutes a key factor that directs progenitor-cell sorting in germ-layer organization during gastrulation.

Patterning Mechanisms of Branched Organs

This work has shown that different cell and tissue types use a remarkably conserved set of tools to undergo branching morphogenesis, and shed important light on the basis of molecular conservation in the formation of branched structures in diverse organs.