Morphogenesis of colonic adenomas in mice treated with N,N'-dimethylhydrazine dihydrochloride.


The morphogenesis of colonic adenomas in ICR mice treated with N,N'-dimethylhydrazine dihydrochloride (DMH) was studied. Treatment of 17 mice with DMH (20 mg/kg/week) for 24 weeks induced 100% incidence of multiple adenomas in the mucosa of the most distal 7 cm of the large intestine. These adenomas were composed of atypical epithelium of the absorptive… (More)


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