1,10-Phenanthroline-5,6-Dione–Based Compounds Are Effective in Disturbing Crucial Physiological Events of Phialophora verrucosa
Morphological changes are required for eukaryotic pathogens to cause disease. However, it is only now becoming clear how such transitions are linked to virulence in human pathogenic fungi. Changing cell size and shape are strategies employed by many of these fungi to survive in the environment and serendipitously also within the host. Conserved signaling pathways regulate morphogenic differentiation in response to environmental and host physiological stimuli. The alterations in cell-surface composition during morphogenesis, in addition to cell size and shape, further link virulence with morphogenesis.