Morphogenesis and molecular considerations on congenital cardiac septal defects.

  title={Morphogenesis and molecular considerations on congenital cardiac septal defects.},
  author={Adriana C. Gittenberger-de Groot and Emmeline E. Calkoen and Robert E. Poelmann and Margot M. Bartelings and Monique R. M. Jongbloed},
  journal={Annals of medicine},
  volume={46 8},
The primary unseptated heart tube undergoes extensive remodeling including septation at the atrial, atrioventricular, ventricular, and ventriculo-arterial level. Alignment and fusion of the septal components is required to ensure full septation of the heart. Deficiencies lead to septal defects at various levels. Addition of myocardium and mesenchymal tissues from the second heart field (SHF) to the primary heart tube, as well as a population of neural crest cells, provides the necessary… CONTINUE READING
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