Morphogen rules: design principles of gradient-mediated embryo patterning

@inproceedings{Briscoe2015MorphogenRD,
  title={Morphogen rules: design principles of gradient-mediated embryo patterning},
  author={James Briscoe and Stephen Small},
  booktitle={Development},
  year={2015}
}
The Drosophila blastoderm and the vertebrate neural tube are archetypal examples of morphogen-patterned tissues that create precise spatial patterns of different cell types. In both tissues, pattern formation is dependent on molecular gradients that emanate from opposite poles. Despite distinct evolutionary origins and differences in time scales, cell biology and molecular players, both tissues exhibit striking similarities in the regulatory systems that establish gene expression patterns that… CONTINUE READING
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