Morphogen pathways as molecular targets for the treatment of fibrosis in systemic sclerosis

@article{Beyer2012MorphogenPA,
  title={Morphogen pathways as molecular targets for the treatment of fibrosis in systemic sclerosis},
  author={Christian Beyer and Clara Dees and J{\"o}rg H. W. Distler},
  journal={Archives of Dermatological Research},
  year={2012},
  volume={305},
  pages={1-8}
}
Wnt-, Hedgehog- and Notch-signaling cascades are morphogen pathways that play crucial roles in development and tissue homeostasis. While morphogen pathways are tightly regulated at multiple levels, inappropriate activation of Wnt, Hedgehog and Notch signaling has been implicated into the pathogenesis of various diseases. In particular, Wnt, Hedgehog and Notch signaling have emerged as central players in the pathogenesis of fibrotic diseases. Here, we will review the pro-fibrotic effects of Wnt… 

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