Morphogen gradients: from generation to interpretation.

@article{Rogers2011MorphogenGF,
  title={Morphogen gradients: from generation to interpretation.},
  author={Katherine W Rogers and Alexander F Schier},
  journal={Annual review of cell and developmental biology},
  year={2011},
  volume={27},
  pages={
          377-407
        }
}
Morphogens are long-range signaling molecules that pattern developing tissues in a concentration-dependent manner. The graded activity of morphogens within tissues exposes cells to different signal levels and leads to region-specific transcriptional responses and cell fates. In its simplest incarnation, a morphogen signal forms a gradient by diffusion from a local source and clearance in surrounding tissues. Responding cells often transduce morphogen levels in a linear fashion, which results in… CONTINUE READING

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