Morphofunctional mitochondrial response to methylglyoxal toxicity in Bufo bufo embryos.

@article{Amicarelli2001MorphofunctionalMR,
  title={Morphofunctional mitochondrial response to methylglyoxal toxicity in Bufo bufo embryos.},
  author={Fernanda Amicarelli and Sabrina Colafarina and Patrizia Cesare and Pierpaolo Aimola and Carmine di Ilio and Michele Miranda and Anna Maria Ragnelli},
  journal={The international journal of biochemistry & cell biology},
  year={2001},
  volume={33 11},
  pages={1129-39}
}
Methylglyoxal (2-oxopropanal) is a reactive alpha-oxoaldehyde that can be formed endogenously mainly as a by-product of glycolytic pathway. It is a cytotoxic compound with significant antiproliferative properties as it can bind, under physiological conditions, to nucleic acids and proteins, forming stable adducts. We have recently shown that exogenous methylglyoxal (150-600 microM) is highly toxic for amphibian embryos where it produces, when added to the culture water, inhibition of cell… CONTINUE READING