Morphofunctional aspects of the blood-brain barrier.

  title={Morphofunctional aspects of the blood-brain barrier.},
  author={B Nico and Domenico Ribatti},
  journal={Current drug metabolism},
  volume={13 1},
The blood-brain barrier (BBB) selectively controls the homeostasis of the Central Nervous System (CNS) environment by the specific structural and biochemical features of the endothelial cells, pericytes and glial endfeet, which represent the cellular components of the mature BBB. Endothelial tight junctions (TJs) are the most important structural component of the BBB, and molecular alteration in the phosphorylation state of some TJs proteins, like ZO-1 or occludin, are crucial in determining… CONTINUE READING
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