Morphing low-affinity ligands into high-avidity nanoparticles by thermally triggered self-assembly of a genetically encoded polymer.

@article{Simnick2010MorphingLL,
  title={Morphing low-affinity ligands into high-avidity nanoparticles by thermally triggered self-assembly of a genetically encoded polymer.},
  author={Andrew Joseph Simnick and Christian A. Valencia and Rihe Liu and Ashutosh Chilkoti},
  journal={ACS nano},
  year={2010},
  volume={4 4},
  pages={
          2217-27
        }
}
Multivalency is the increase in avidity resulting from the simultaneous interaction of multiple ligands with multiple receptors. This phenomenon, seen in antibody-antigen and virus-cell membrane interactions, is useful in designing bioinspired materials for targeted delivery of drugs or imaging agents. While increased avidity offered by multivalent targeting is attractive, it can also promote nonspecific receptor interaction in nontarget tissues, reducing the effectiveness of multivalent… CONTINUE READING
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