Morphine withdrawal in cortical slices: suppression by Ca2+-channel inhibitors of abstinence-induced [3H]-noradrenaline release.

@article{PellegriniGiampietro1988MorphineWI,
  title={Morphine withdrawal in cortical slices: suppression by Ca2+-channel inhibitors of abstinence-induced [3H]-noradrenaline release.},
  author={Domenico E. Pellegrini-Giampietro and Lucia Bacciottini and Vincenzo Carl{\`a} and Flavio Moroni},
  journal={British journal of pharmacology},
  year={1988},
  volume={93 3},
  pages={535-40}
}
1. The effects of morphine withdrawal were evaluated in vitro by monitoring the actions of naloxone on the depolarization-induced release of [3H]-noradrenaline (NA) in cortical slices taken from naïve or dependent rats. The effects of dihydropyridine molecules acting on Ca2+-channels (nimodipine and Bay K 8644) were also studied in this model. 2. Naloxone… CONTINUE READING