Morphine withdrawal decreases responding reinforced by sucrose self-administration in progressive ratio.

@article{Zhang2007MorphineWD,
  title={Morphine withdrawal decreases responding reinforced by sucrose self-administration in progressive ratio.},
  author={Dengke Zhang and Xuhui Zhou and Xuyi Wang and Xiaojun Xiang and Hong-xian Chen and Wei Hao},
  journal={Addiction biology},
  year={2007},
  volume={12 2},
  pages={152-7}
}
Previous studies have shown that withdrawal from psychostimulant drugs such as d-amphetamine or methamphetamine decreases motivation to work for a natural reinforcement, which is thought to be associated with the withdrawal-induced depressive state and hypofunction of the mesolimbic dopamine system. However, to our knowledge, studies exploring the effect of… CONTINUE READING