Morphine versus mexiletine for treatment of postamputation pain: a randomized, placebo-controlled, crossover trial.

@article{Wu2008MorphineVM,
  title={Morphine versus mexiletine for treatment of postamputation pain: a randomized, placebo-controlled, crossover trial.},
  author={Christopher L. Wu and Shefali Agarwal and Prabhav K Tella and B Christina L Klick and Michael R. Clark and Jennifer A. Haythornthwaite and Mitchell B. Max and Srinivasa N Raja},
  journal={Anesthesiology},
  year={2008},
  volume={109 2},
  pages={289-96}
}
BACKGROUND Stump and phantom pains are debilitating sequelae of amputations that are often resistant to treatment. The efficacy of pharmacologic therapies, including opioids and sodium channel blockers, for postamputation pain is uncertain. METHODS The authors conducted a double-blind, randomized, placebo-controlled, crossover study in adult patients with postamputation pain of 6 months or longer and greater than 3 on a 0-10 numeric pain rating scale. Each of the three treatment periods… CONTINUE READING
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