Morphine tolerance and physical dependence: reversal of opioid inhibition to enhancement of cyclic AMP formation.

@article{Wang1995MorphineTA,
  title={Morphine tolerance and physical dependence: reversal of opioid inhibition to enhancement of cyclic AMP formation.},
  author={Liping Wang and Alan R. Gintzler},
  journal={Journal of neurochemistry},
  year={1995},
  volume={64 3},
  pages={1102-6}
}
This laboratory has previously demonstrated that the mu-selective opiate receptor agonist sufentanil can produce a naloxone-reversible increase or decrease in the stimulated formation of cyclic AMP (cAMP) in the myenteric plexus, depending on the concentration of opioid used. On the basis of these results, it was suggested that mu-opiate receptors are positively as well as negatively coupled to adenylyl cyclase. In the present study, the effect of chronic morphine exposure, in vivo, on the… CONTINUE READING