Morphine reduces the threshold of helium preconditioning against myocardial infarction: the role of opioid receptors in rabbits.

OBJECTIVES Brief, repetitive administration of helium before prolonged coronary artery occlusion and reperfusion protects myocardium against infarction. Opioid receptors mediate the cardioprotective effects of ischemic pre- and postconditioning, but whether these receptors also play a role in helium preconditioning is unknown. The authors tested the… (More)