Morphine reciprocally regulates IL-10 and IL-12 production by monocyte-derived human dendritic cells and enhances T cell activation.

@article{Messmer2006MorphineRR,
  title={Morphine reciprocally regulates IL-10 and IL-12 production by monocyte-derived human dendritic cells and enhances T cell activation.},
  author={Davorka Messmer and Ikusuke Hatsukari and Naoko Hitosugi and Ingo G. H. Schmidt-Wolf and Pravin C. Singhal},
  journal={Molecular medicine},
  year={2006},
  volume={12 11-12},
  pages={
          284-90
        }
}
We evaluated the effect of morphine on human dendritic cells (DCs). Interestingly, immature DCs were found to express all 3 (mu, kappa, delta) opioid receptors on the cell surface. Chronic morphine treatment (10(-8) to 10(-12) M) during the development of DCs from monocytes augmented LPS-induced upregulation of HLA-DR, CD86, CD80, and CD83 and increased the T cell stimulatory capacity of DCs, which could be inhibited by naloxone, an opioid receptor antagonist. The change in surface phenotype… CONTINUE READING

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