Morphine preference in rats previously morphine dependent.

  title={Morphine preference in rats previously morphine dependent.},
  author={S H Dai and Stanley Sai-chuen Hui and Clive W. Ogle},
  journal={Pharmacological research communications},
  volume={16 5},
Morphine preference and tendency to relapse to morphine tolerance and dependence were studied in rats which were previously made morphine dependent. Tolerance to, and physical dependence on, morphine were initially produced by administration of increasing concentrations of morphine sulphate in 5% sucrose solution for 3 weeks. A test for drinking preference… CONTINUE READING