Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation.

@article{Grace2016MorphinePP,
  title={Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation.},
  author={Peter M Grace and Keith A Strand and Erika L Galer and Daniel Urb{\'a}n and Xiaohui Wang and Michael V Baratta and Timothy J Fabisiak and Nathan D Anderson and Kejun Cheng and L I Greene and Debra L Berkelhammer and Yingning Zhang and Amanda Lynne Ellis and Hang Yin and Serge Campeau and Kenner C. Rice and Bryan L. Roth and Steven F. Maier and Linda R. Watkins},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 24},
  pages={E3441-50}
}
Opioid use for pain management has dramatically increased, with little assessment of potential pathophysiological consequences for the primary pain condition. Here, a short course of morphine, starting 10 d after injury in male rats, paradoxically and remarkably doubled the duration of chronic constriction injury (CCI)-allodynia, months after morphine ceased. No such effect of opioids on neuropathic pain has previously been reported. Using pharmacologic and genetic approaches, we discovered… CONTINUE READING

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