Morphine-mimetic anti-paratypic antibodies: cross-reactive properties.


Polyclonal, anti-idiotypic, rabbit antibodies have been raised against four murine monoclonal anti-morphine Fab fragments. The antibody preparations, after affinity purification, have been shown to contain an anti-paratypic fraction which reversibly inhibits morphine binding to the anti-morphine antibodies and to cellular opiate receptors. Using some of the unique properties of this system, for the first time cross-reactivities of anti-paratypic antibodies with the monoclonal anti-morphine IgGs have been examined including competition for the same binding sites by a classical opiate agonist/antagonist pair.

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@article{Glasel1986MorphinemimeticAA, title={Morphine-mimetic anti-paratypic antibodies: cross-reactive properties.}, author={Jay A Glasel and Lenore A Pelosi}, journal={Biochemical and biophysical research communications}, year={1986}, volume={136 3}, pages={1177-84} }