Morphine metabolism in children.

  title={Morphine metabolism in children.},
  author={Imti Choonara and Patrick McKay and Ruediger Hain and Anders Rane},
  journal={British journal of clinical pharmacology},
  volume={28 5},
1. The metabolism of morphine was studied in 12 children and nine premature neonates on a continuous infusion of morphine (10-360 micrograms kg-1 h-1). 2. The mean plasma clearance of morphine was significantly higher in children than neonates (25.7 and 4.7 ml min-1 kg-1, respectively) (P less than 0.01). 3. All the neonates and children had detectable concentrations of morphine-3-glucuronide (M3G) in plasma. All the children and five neonates had detectable concentrations of morphine-6… CONTINUE READING

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