Morphine lowering of self-stimulation thresholds: lack of tolerance with long-term administration.

@article{Esposito1977MorphineLO,
  title={Morphine lowering of self-stimulation thresholds: lack of tolerance with long-term administration.},
  author={Ralph Umberto Esposito and Conan Kornetsky},
  journal={Science},
  year={1977},
  volume={195 4274},
  pages={
          189-91
        }
}
Rats were given increasing amounts of morphine over a period of weeks in order to achieve tolerance. Doses of the drug which initially reduced the threshold for self-stimulation behavior continued to do so after long-term administration. These results demonstrate a persistent central effect of morphine which may be related to the opiate "high." 
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