Morphine inhibits the carrageenan‐induced oedema and the chemoluminescence of leucocytes stimulated by zymosan

@article{Gyires1985MorphineIT,
  title={Morphine inhibits the carrageenan‐induced oedema and the chemoluminescence of leucocytes stimulated by zymosan},
  author={Kl{\'a}ra Gyires and Imre Budav{\'a}ri and S F{\"u}rst and Imre Molnar},
  journal={Journal of Pharmacy and Pharmacology},
  year={1985},
  volume={37}
}
Morphine inhibited the oedema formation induced by carrageenan. The anti‐inflammatory activity developed 120 min after carrageenan injection, suggesting that inhibition of the kinin phase might be partly responsible. This assumption is supported by the findings that morphine inhibited bradykinin oedema but did not influence oedema formation induced by histamine, 5‐HT or PGE2. The anti‐inflammatory activity of morphine was partially inhibited by naloxone (0.5−1 mg kg−1) in the carrageenan oedema… 

Intrathecally Injected Morphine Inhibits Inflammatory Paw Edema: The Involvement of Nitric Oxide and Cyclic-Guanosine Monophosphate

The idea that morphine can act on opioid receptors at the spinal level to produce antiedematogenic effect is supported, and that the NO/cGMP pathway seems to be an important mediator in this effect.

OPIOID ANALGESICS POTENTIATE THE ANTI-INFLAMMATORY AND INHIBIT ULCEROGENIC ACTIVITY OF ASPIRIN.

Therapeutic equivalent doses of morphine, pethidine and pentazocine investigated for their possible anti-inflammatory and ulcerogenic activity in normal as well as in aspirin treated albino rats produced significant anti inflammatory activity, almost comparable to that of Aspirin.

Peptide opioids and morphine effects on inflammatory process

The naloxone-sensitive impairment by morphine of CD11b-CD18 complex surface expression observed could play a role in opioid inhibition of granulocyte activation.

Involvement of sympathetic efferents but not capsaicin-sensitive afferents in nociceptin-mediated dual control of rat synovial blood flow.

  • J. McDougall
  • Biology, Medicine
    American journal of physiology. Regulatory, integrative and comparative physiology
  • 2003
Results show that, in the rat knee, peripheral administration of nociceptin primarily causes a sympathetically mediated vasoconstriction, and high-dose nocICEptin produces a vasodilatatory response that is likely due to the direct action of nOCiceptin on vascular smooth muscle and not by a neurogenic mechanism.

Involvement of central opioid receptors in protective effects of methadone on experimental colitis in rats

The opioid receptors mainly the central opioid receptors may mediate the protective actions of methadone on the experimental model of inflammatory bowel disease in rat.

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EVIDENCE FOR AN ACTION OF MORPHINE AND THE ENKEPHALINS ON SENSORY NERVE ENDINGS IN THE MOUSE PERITONEUM

It is concluded that morphine and its congeners can produce an antinociceptive effect by an action within the mouse peritoneum, presumably by interacting with one or more types of opioid receptors which may be situated on sensory nerve endings.

Prostaglandins reverse inhibition of electrically-induced contractions of guinea pig ileum by morphine, indomethacin and acetylsalicylic acid.

It is shown that certain prostaglandins, in particular PGE1 and E2, also reverse this action of morphine and other narcotics.

INHIBITION BY MORPHINE OF PROSTAGLANDIN E1‐STIMULATED SECRETION AND CYCLIC ADENOSINE 3′,5′‐MONOPHOSPHATE FORMATION IN THE RAT JEJUNUM in vivo

It is demonstrated that PGE1 stimulates intestinal fluid secretion by increasing mucosal cyclic AMP levels and net water flux, and the antidiarrhoeal effect of morphine can be explained by its inhibition of the PGE‐mediated increase in cyclicAMP levels, which, in turn, leads to a reduction in intestinal secretion.

Opiate agonists inhibit neurogenic plasma extravasation in the rat.