Morphine inhibits murine dendritic cell IL-23 production by modulating Toll-like receptor 2 and Nod2 signaling.

@article{Wang2011MorphineIM,
  title={Morphine inhibits murine dendritic cell IL-23 production by modulating Toll-like receptor 2 and Nod2 signaling.},
  author={Jinghua Wang and Jing Ma and Rick Charboneau and Roderick A. Barke and Sabita Roy},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 12},
  pages={
          10225-32
        }
}
IL-23, produced by dendritic cells (DCs) and macrophages, plays a critical role in innate immunity against bacterial infection. Our previous studies show that morphine disrupts the IL-23/IL-17 mediated pulmonary mucosal host defense and increases susceptibility to Streptococcus pneumoniae lung infection. To determine the mechanism by which morphine modulates IL-23 production, mouse bone marrow-derived dendritic cells (BMDCs) and macrophages (BMDMs) were treated with morphine, and infected with… CONTINUE READING
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Morphine Modulates IL-23 in Dendritic Cells 10232 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

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