Morphine induces the release of CCL5 from astrocytes: potential neuroprotective mechanism against the HIV protein gp120.

@article{Avdoshina2010MorphineIT,
  title={Morphine induces the release of CCL5 from astrocytes: potential neuroprotective mechanism against the HIV protein gp120.},
  author={Valeriya Avdoshina and Francesca Biggio and Guillermo A Palchik and Lee A. Campbell and Italo Mocchetti},
  journal={Glia},
  year={2010},
  volume={58 13},
  pages={1630-9}
}
A number of human immunodeficiency virus type-1 (HIV) positive subjects are also opiate abusers. These individuals are at high risk to develop neurological complications. However, little is still known about the molecular mechanism(s) linking opiates and HIV neurotoxicity. To learn more, we exposed rat neuronal/glial cultures prepared from different brain areas to opiate agonists and HIV envelope glycoproteins gp120IIIB or BaL. These strains bind to CXCR4 and CCR5 chemokine receptors… CONTINUE READING

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