Morphine induces apoptosis in murine thymocytes in vivo but not in vitro: involvement of both opiate and glucocorticoid receptors.

Abstract

We tested the hypothesis that the previously observed loss of thymic lymphocytes in mice after treatment with time-release morphine pellets was occurring through the process of apoptosis. Apoptosis is a form of cell death, distinct from necrosis, which involves a specific endonuclease that fragments the cell's own DNA. Forty-eight hours after implantation… (More)

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@article{Fuchs1993MorphineIA, title={Morphine induces apoptosis in murine thymocytes in vivo but not in vitro: involvement of both opiate and glucocorticoid receptors.}, author={Berthold Fuchs and Stephen B Pruett}, journal={The Journal of pharmacology and experimental therapeutics}, year={1993}, volume={266 1}, pages={417-23} }