Morphine induces CD4+ T cell IL-4 expression through an adenylyl cyclase mechanism independent of the protein kinase A pathway.

@article{Roy2005MorphineIC,
  title={Morphine induces CD4+ T cell IL-4 expression through an adenylyl cyclase mechanism independent of the protein kinase A pathway.},
  author={Sabita Roy and Jinghua Wang and Richard Charboneau and Horace H. Loh and Roderick A. Barke},
  journal={Journal of immunology},
  year={2005},
  volume={175 10},
  pages={
          6361-7
        }
}
Impaired host defense mechanisms after major operative procedures and trauma are recognized as important factors in the development of infectious complication. Trauma is associated with impaired cellular immunity and CD4+ T cell Th2 differentiation. We have previously implicated morphine treatment as a possible mechanism for Th2 differentiation after injury. In this investigation we first establish that morphine treatment in vivo results in Th2 differentiation and that this effect is mediated… CONTINUE READING

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