Morphine-induced long-term sensitization to the locomotor effects of morphine and amphetamine depends on the temporal pattern of the pretreatment regimen

@article{Vanderschuren1997MorphineinducedLS,
  title={Morphine-induced long-term sensitization to the locomotor effects of morphine and amphetamine depends on the temporal pattern of the pretreatment regimen},
  author={Louk J. M. J. Vanderschuren and Guno H. K. Tjon and Patrizia Nestby and Arie H. Mulder and Anton N M Schoffelmeer and Taco J. de Vries},
  journal={Psychopharmacology},
  year={1997},
  volume={131},
  pages={115-122}
}
The development of behavioural sensitization is thought to depend on the dose and temporal pattern of drug treatment. Previous studies have shown that two distinct morphine pretreatment regimens cause different long-term neuroadaptations in rat striatum. Therefore, in the present study the ability of these pretreatment regimens to induce long-term behavioural sensitization was investigated. One pretreatment regimen, termed “chronic”, consisted of three daily injections, for 5 days, with… CONTINUE READING

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