Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor.

@article{Cooke2015MorphineinducedIO,
  title={Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor.},
  author={Alexandra E. Cooke and S. D. Oldfield and Cornelius Krasel and Stuart James Mundell and Graeme Henderson and Eamonn Kelly},
  journal={British journal of pharmacology},
  year={2015},
  volume={172 2},
  pages={593-605}
}
BACKGROUND AND PURPOSE Naturally occurring single-nucleotide polymorphisms (SNPs) within GPCRs can result in alterations in various pharmacological parameters. Understanding the regulation and function of endocytic trafficking of the μ-opioid receptor (MOP receptor) is of great importance given its implication in the development of opioid tolerance. This study has compared the agonist-dependent trafficking and signalling of L83I, the rat orthologue of a naturally occurring variant of the MOP… CONTINUE READING