Morphine in combination with metabotropic glutamate receptor antagonists on schedule-controlled responding and thermal nociception.

@article{Fischer2008MorphineIC,
  title={Morphine in combination with metabotropic glutamate receptor antagonists on schedule-controlled responding and thermal nociception.},
  author={Bradford D. Fischer and Eric I. Zimmerman and Mitchell J. Picker and Linda A. Dykstra},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2008},
  volume={324 2},
  pages={732-9}
}
The present study examined the interactive effects of morphine in combination with metabotropic glutamate (mGlu) receptor antagonists on schedule-controlled responding and thermal nociception. Drug interaction data were examined with isobolographic and dose-addition analysis. Morphine, the mGlu1 receptor antagonist JNJ16259685 [(3,4-dihydro-2H-pyrano-[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone], the mGlu5 receptor antagonist MPEP [2-methyl-6-(phenylethynyl)pyridine hydrochloride… CONTINUE READING