Morphine hyperalgesia: A case report

@article{Wilson2003MorphineHA,
  title={Morphine hyperalgesia: A case report},
  author={G. Wilson and G. Reisfield},
  journal={American Journal of Hospice and Palliative Medicine},
  year={2003},
  volume={20},
  pages={459 - 461}
}
We report a case of a patient with metastatic testicular cancer and intractable pain refractory to massive doses of oral, intravenous, and intrathecal (IT) opioids supported by analgesic adjuvants. During our efforts to control his pain, the patient exhibited opioid-induced hyperalgesia, an uncommon but important phenomenon seen with high-dose opioid therapy. With appropriate opioid adjustment—in this case reduction of intrathecal morphine dosage by a factor of 100—the condition rapidly… Expand
A differential diagnosis of hyperalgesia, toxicity, and withdrawal from intrathecal morphine infusion.
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Intrathecal analgesia for refractory cancer pain
Opioid tolerance and hyperalgesia.
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