Morphine glucuronidation in premature neonates.

  title={Morphine glucuronidation in premature neonates.},
  author={R. P. Hartley and Michael W Quinn and Martine Green and Malcolm I Levene},
  journal={British journal of clinical pharmacology},
  volume={35 3},
The glucuronidation of morphine was investigated in 10 premature neonates (postnatal age < 24 h at initiation of treatment) following 24 h of therapy (2 h loading infusion, followed by a constant rate infusion). Morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) were measured in plasma obtained at 24 h in all babies. Plasma… CONTINUE READING