Morphine exerts testosterone-like effects in the hypothalamus of the castrated male rat.

@article{Cicero1980MorphineET,
  title={Morphine exerts testosterone-like effects in the hypothalamus of the castrated male rat.},
  author={Theodore J. Cicero and Edward R Meyer and Sister Mary Gabriel and R. D. Bell and C. Wilcox},
  journal={Brain research},
  year={1980},
  volume={202 1},
  pages={151-64}
}
Previous research has indicated that endogenous opioids participate in the regulation of activity in the hypothalamic-pituitary-luteinizing hormone (LH) axis and mediate the negative feedback control exerted by testosterone. If this assumption is correct, then two predictions can be made. First, the effects of testosterone should be competitively inhibited by narcotic antagonists; and, second, opiates should mimic the acute and chronic effects of testosterone in the castrated male rat. The… CONTINUE READING

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