Morphine disposition in opiate-intoxicated patients: relevance of nonspecific opiate immunoassays.

@article{Got1994MorphineDI,
  title={Morphine disposition in opiate-intoxicated patients: relevance of nonspecific opiate immunoassays.},
  author={Pierre Got and Fr{\'e}d{\'e}ric J. Baud and Pierre Sandouk and Odile Diamant-Berger and Jean Michel G. Scherrmann},
  journal={Journal of analytical toxicology},
  year={1994},
  volume={18 4},
  pages={189-94}
}
The use of routine nonspecific immunoassays to detect or quantitate opiates in biological fluids raises the question of the relevance of such immunoassays in the investigation of opiate overdose disposition. We investigated the plasma disposition of morphine in 13 patients intoxicated by the intravascular (i.v.) (n = 5) or oral routes (n = 8) using both a highly morphine-specific antibody radioimmunoassay (RIA) and a nonspecific morphine RIA. Both RIAs showed a first-order elimination rate… CONTINUE READING