Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation

@inproceedings{Chen2015MorphineDG,
  title={Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation},
  author={Ming Chen and Yanfang Zhao and Hualan Yang and Wenjie Luan and Jiaojiao Song and Dongyang Cui and Yi Dong and Bin Bin Lai and Lan Ma and Ping Zheng and Wolfram Schultz},
  booktitle={eLife},
  year={2015}
}
One reported mechanism for morphine activation of dopamine (DA) neurons of the ventral tegmental area (VTA) is the disinhibition model of VTA-DA neurons. Morphine inhibits GABA inhibitory neurons, which shifts the balance between inhibitory and excitatory input to VTA-DA neurons in favor of excitation and then leads to VTA-DA neuron excitation. However, it is not known whether morphine has an additional strengthening effect on excitatory input. Our results suggest that glutamatergic input to… CONTINUE READING
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