Morphine deprivation increases self-administration of the fast- and short-acting mu-opioid receptor agonist remifentanil in the rat.

@article{Cooper2008MorphineDI,
  title={Morphine deprivation increases self-administration of the fast- and short-acting mu-opioid receptor agonist remifentanil in the rat.},
  author={Ziva D Cooper and Yen Nhu-Thi Truong and Yong-Gong Shi and J. H. Woods},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2008},
  volume={326 3},
  pages={920-9}
}
Opiate dependence and withdrawal have long been hypothesized to enhance the reinforcing effects of opiates; however, opiate agonist self-administration in these states has yet to be systematically assessed. To address this issue, the reinforcing property of the short-acting mu-opioid agonist, remifentanil, was assessed in morphine-dependent (MD), morphine-dependent and -withdrawn (MW), and nondependent, control (C) rats. Dependence was established by twice daily administration of increasing… CONTINUE READING

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