Morphine decreases peripheral vascular resistance and increases capacitance in man.

@article{Hsu1979MorphineDP,
  title={Morphine decreases peripheral vascular resistance and increases capacitance in man.},
  author={H. Hsu and R. Hickey and A. R. Forbes},
  journal={Anesthesiology},
  year={1979},
  volume={50 2},
  pages={
          98-102
        }
}
The response of the human peripheral circulation to morphine in large doeses independent of cardiac and respiratory influences has not been delineated. In 28 patients during cardiopulmonary bypass, alterations of peripheral vascular resistance (PVR) and capacitance in response to rapid arterial injection of morphine, 0.5 mg/kg or 1 mg/kg alone, or preceeded by promethazine, 1 mg/kg, naloxone, 10 mug/kg, or naloxone, 20 mug/kg, were recorded over 15 min at a constant perfusion rate. Both doses… Expand
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