Morphine compared with diamorphine

  title={Morphine compared with diamorphine},
  author={S. L. Robinson and David J. Rowbotham and G. Smith},
The dose requirements and side effects of morphine were compared with those of diamorphine administered by patient‐controlled analgesia in 40 patients following elective total hip replacement. Patients were allocated randomly to receive in a double‐blind manner either morphine or diamorphine for postoperative pain relief. There were no significant differences between the two groups with regard to postoperative sedation, nausea, well‐being, pain relief and requirements for antiemetic drugs. The… 

Dose requirements, efficacy and side effects of morphine and pethidine delivered by patient-controlled analgesia after gynaecological surgery.

We have compared the dose requirements and side effects of morphine with those of pethidine when administered by patient-controlled analgesia in 40 patients (ASA I-II, 20-65 yr) after elective total

Hypoxaemia and pain relief after lower abdominal surgery: comparison of extradural and patient-controlled analgesia.

Extradural infusion analgesia produced the smallest pain scores from 12 to 24 h after surgery (P < 0.05), and the group using patient-controlled analgesia received more diamorphine and suffered a greater incidence of emetic sequelae.

efficacy . analgesia : assessment of safety and Intranasal diamorphine for paediatric

Intranasal diamorphine is an effective, safe, and acceptable method ofanalgesia for children requiring opiates in the A&E department.

Patient-controlled epidural diamorphine for post-operative pain: verbal rating and visual analogue assessments of pain.

Epidural PCA began when the intraoperative epidural block with bupivacaine wore off enough for the patient to request treatment, and clinically acceptable analgesia was maintained without undue sedation for 48 h, though pain on coughing was less well controlled than pain at rest.

Side Effect Rates of Opioids in Equianalgesic Doses Via Intravenous Patient-Controlled Analgesia: A Systematic Review and Network Meta-analysis.

The opiate chosen for treatment most likely has little effect on the incidence of pruritus and nausea/vomiting, although considerable differences exist in terms of better and worse opioids in the presented rankings.

Intranasal diamorphine for paediatric analgesia: assessment of safety and efficacy.

Intranasal diamorphine is an effective, safe, and acceptable method of analgesia for children requiring opiates in the A & E department.

Effects of High-Dose Heroin versus Morphine in Intravenous Drug Users: A Randomised Double-Blind Crossover Study

It is concluded that as heroin produces fewer side effects it is the preferred highdose maintenance prescription to morphine, and the perceived euphoric effects are limited in both substances.

Intranasal Diamorphine as an Alternative to Intramuscular Morphine

Intranasal diamorphine provided the same overall degree of pain relief as intramuscular morphine, but with a quicker onset of action, and was found to be well tolerated with an acceptable safety profile.

Patient-controlled analgesia.

Patient-controlled delivery systems deliver drugs at a rate which is controlled by the patient in order to achieve plasma concentrations consistent with acceptable efficacy and minimal side-effects to evaluate alternative methods of providing postoperative analgesia.

Multicentre randomised controlled trial of nasal diamorphine for analgesia in children and teenagers with clinical fractures

Nasal diamorphine spray should be the preferred method of pain relief in children and teenagers presenting to emergency departments in acute pain with clinical fractures and should be used in place of intramuscular morphine.



Extradural versus intramuscular diamorphine

The relative proportion of spinal binding may be increased after extradural administration and this may be reflected in the prolonged analgesia observed, which was more prolonged following extraduraladministration.

Studies of drugs given before anaesthesia. XI. Diamorphine (heroin) and morphine.

Diamorphine was found to have a shorter duration of action and this may account for the higher incidence of excitatory phenomenon and more rapid recovery from anaesthesia associated with its use.

Subjective effects of heroin and morphine in normal subjects.

Diamorphine its chemistry, pharmacology and clinical use

  • 1988

The use of diamorphine in acute pain

  • Diamorphine its chemistry , pharmacology and clinical use
  • 1988