Morphine and metabolite behavior after different routes of morphine administration: Demonstration of the importance of the active metabolite morphine‐6‐glucuronide

@article{Osborne1990MorphineAM,
  title={Morphine and metabolite behavior after different routes of morphine administration: Demonstration of the importance of the active metabolite morphine‐6‐glucuronide},
  author={R. Osborne and S. Joel and D. Trew and M. Slevin},
  journal={Clinical Pharmacology & Therapeutics},
  year={1990},
  volume={47}
}
The pharmacokinetic parameters of morphine, morphine‐6‐glucuronide, and morphine‐3‐glucuronide were studied after single‐dose morphine administration by five different routes. The quantitative significance of the active metabolite morphine‐6‐glucuronide was assessed, and the effects of novel dosing forms on morphine metabolism and distribution were examined. After administration of intravenous morphine the morphine‐6‐glucuronide plasma AUC exceeded that of morphine. After administration of oral… Expand
409 Citations
Pharmacology of morphine metabolites
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