Morphine- and buprenorphine-induced analgesia and antihyperalgesia in a human inflammatory pain model: a double-blind, randomized, placebo-controlled, five-arm crossover study

@inproceedings{Ravn2013MorphineAB,
  title={Morphine- and buprenorphine-induced analgesia and antihyperalgesia in a human inflammatory pain model: a double-blind, randomized, placebo-controlled, five-arm crossover study},
  author={Pernille Ravn and Erik Lilja Secher and Ulrik Skram and Trine Therkildsen and Lona Louring Christrup and Mads Utke Werner},
  booktitle={Journal of pain research},
  year={2013}
}
PURPOSE Opioid therapy is associated with the development of tolerance and paradoxically increased sensitivity to pain. It has been suggested that buprenorphine is associated with a higher antihyperalgesia/analgesia ratio than μ-opioid receptor agonists. The primary outcome of this study was therefore to investigate relative differences in antihyperalgesia and analgesia effects between morphine and buprenorphine in an inflammatory pain model in volunteers. The secondary outcome was to examine… CONTINUE READING
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