Morphine- and anandamide-stimulated nitric oxide production inhibits presynaptic dopamine release.

@article{Stefano1997MorphineAA,
  title={Morphine- and anandamide-stimulated nitric oxide production inhibits presynaptic dopamine release.},
  author={G B Stefano and Beatrice Salzet and Christos M Rialas and M Pope and Adam B Kustka and K. Butkins Neenan and Scott Pryor and Michel Salzet},
  journal={Brain research},
  year={1997},
  volume={763 1},
  pages={63-8}
}
Morphine and anandamide stimulate the release of nitric oxide (NO) in diverse tissues. The present study examines the consequences of this action on neurotransmitter release in ganglia from two invertebrates: ventral chain ganglia from the leech Hirudo medicinalis and the pedal ganglion from the mussel Mytilus edulis. In these ganglia, preloaded serotonin (5-HT) and dopamine (DA) can be released by 50 mM KCl. Anandamide, an endogenous cannabinoid substance, suppresses the potassium-stimulated… CONTINUE READING