Morphine and alfentanil permeability through the spinal dura, arachnoid, and pia mater of dogs and monkeys.

@article{Bernards1990MorphineAA,
  title={Morphine and alfentanil permeability through the spinal dura, arachnoid, and pia mater of dogs and monkeys.},
  author={Christopher M. Bernards and Harlan F. Hill},
  journal={Anesthesiology},
  year={1990},
  volume={73 6},
  pages={1214-9}
}
Little information exists about which spinal meninx is the principal permeability barrier between the epidural space and the spinal cord or about what physicochemical properties of drug molecules govern their meningeal permeability. To better understand these aspects of epidural pharmacokinetics, the authors measured the permeability of morphine and alfentanil through the different components of the spinal meninges-dura mater, arachnoid mater, and pia mater-of dogs and monkeys in vitro. Live… CONTINUE READING

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