Morphine and Fentanyl Differently Affect MOP and NOP Gene Expression in Human Neuroblastoma SH-SY5Y Cells

Abstract

Morphine is widely used for the treatment of severe acute and chronic pain, but long-term therapy rapidly leads to tolerance. Morphine effects are mediated by μ opioid receptor (MOP) activation as well as for fentanyl that, in contrast to morphine, induces less tolerance to analgesia. The mechanisms underlying opioid tolerance involve complex processes… (More)
DOI: 10.1007/s12031-013-0019-3

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@article{Caputi2013MorphineAF, title={Morphine and Fentanyl Differently Affect MOP and NOP Gene Expression in Human Neuroblastoma SH-SY5Y Cells}, author={Francesca Felicia Caputi and Francesca Lattanzio and Donatella Carretta and Daniela Mercatelli and S Candeletti and Patrizia Romualdi}, journal={Journal of Molecular Neuroscience}, year={2013}, volume={51}, pages={532-538} }