Morphine and ABT-594 (a nicotinic acetylcholine agonist) exert centrally mediated antinociception in the rat cyclophosphamide cystitis model of visceral pain.

@article{Joshi2008MorphineAA,
  title={Morphine and ABT-594 (a nicotinic acetylcholine agonist) exert centrally mediated antinociception in the rat cyclophosphamide cystitis model of visceral pain.},
  author={Shailen K. Joshi and Joe P Mikusa and Brenda Weaver and Prisca Honore},
  journal={The journal of pain : official journal of the American Pain Society},
  year={2008},
  volume={9 2},
  pages={146-56}
}
UNLABELLED A visceral pain model incorporating use of cyclophosphamide (CP) to induce bladder inflammation has been described. CP treatment in rats produces changes in behavior (abnormal postures and eye closure) and respiration rate indicative of visceral pain. We characterized the dose-dependency and progression of CP-induced cystitis pain after intraperitoneal (i.p.) CP. The behavioral and respiration rate changes were ameliorated by systemic morphine and ABT-594 [(R)-5-(2-azetidinylmethoxy… CONTINUE READING
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