Morphine alters the selective association between mu-opioid receptors and specific RGS proteins in mouse periaqueductal gray matter

@article{Garzn2005MorphineAT,
  title={Morphine alters the selective association between mu-opioid receptors and specific RGS proteins in mouse periaqueductal gray matter},
  author={Javier Garz{\'o}n and Mar{\'i}a Rodr{\'i}guez-Mu{\~n}oz and Pilar S{\'a}nchez-Bl{\'a}zquez},
  journal={Neuropharmacology},
  year={2005},
  volume={48},
  pages={853-868}
}
In the CNS, several regulators of G-protein signalling (RGS) modulate the activity of mu-opioid receptors. In pull-down assays performed on membranes from mouse periaqueductal gray matter (PAG), mu-opioid receptors co-precipitated with delta-opioid receptors, Gi/o/z/q proteins, and the regulators of G-protein signalling RGS4, RGS9-2, RGS14, RGSZ1 and RGSZ2. No RGS2, RGS7, RGS10 and RGS11 proteins were associated with the mu receptors in these PAG membranes. In mice, an intracerebroventricular… Expand
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TLDR
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