Morphine-6-glucuronide: morphine's successor for postoperative pain relief?

@article{Dorp2006Morphine6glucuronideMS,
  title={Morphine-6-glucuronide: morphine's successor for postoperative pain relief?},
  author={Eveline L A van Dorp and Raymonda R Romberg and Elise Y. Sarton and James G. Bovill and Albert Dahan},
  journal={Anesthesia and analgesia},
  year={2006},
  volume={102 6},
  pages={1789-97}
}
In searching for an analgesic with fewer side effects than morphine, examination of morphine's active metabolite, morphine-6-glucuronide (M6G), suggests that M6G is possibly such a drug. In contrast to morphine, M6G is not metabolized but excreted via the kidneys and exhibits enterohepatic cycling, as it is a substrate for multidrug resistance transporter proteins in the liver and intestines. M6G exhibits a delay in its analgesic effect (blood-effect site equilibration half-life 4-8 h), which… CONTINUE READING
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