Morphine-6-Glucuronide: Morphine's Successor for Postoperative Pain Relief?

  title={Morphine-6-Glucuronide: Morphine's Successor for Postoperative Pain Relief?},
  author={Eveline L A van Dorp and R. Romberg and E. Sarton and J. Bovill and A. Dahan},
  journal={Anesthesia & Analgesia},
  • Eveline L A van Dorp, R. Romberg, +2 authors A. Dahan
  • Published 2006
  • Medicine
  • Anesthesia & Analgesia
  • In searching for an analgesic with fewer side effects than morphine, examination of morphine's active metabolite, morphine-6-glucuronide (M6G), suggests that M6G is possibly such a drug. In contrast to morphine, M6G is not metabolized but excreted via the kidneys and exhibits enterohepatic cycling, as it is a substrate for multidrug resistance transporter proteins in the liver and intestines. M6G exhibits a delay in its analgesic effect (blood-effect site equilibration half-life 4–8 h), which… CONTINUE READING
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