Morphine-6-Glucuronide: Morphine's Successor for Postoperative Pain Relief?
@article{Dorp2006Morphine6GlucuronideMS, title={Morphine-6-Glucuronide: Morphine's Successor for Postoperative Pain Relief?}, author={Eveline L A van Dorp and R. Romberg and E. Sarton and J. Bovill and A. Dahan}, journal={Anesthesia & Analgesia}, year={2006}, volume={102}, pages={1789-1797} }
In searching for an analgesic with fewer side effects than morphine, examination of morphine's active metabolite, morphine-6-glucuronide (M6G), suggests that M6G is possibly such a drug. In contrast to morphine, M6G is not metabolized but excreted via the kidneys and exhibits enterohepatic cycling, as it is a substrate for multidrug resistance transporter proteins in the liver and intestines. M6G exhibits a delay in its analgesic effect (blood-effect site equilibration half-life 4–8 h), which… CONTINUE READING
53 Citations
Antinociceptive effects and toxicity of morphine-6-O-sulfate sodium salt in rat models of pain.
- Medicine
- European journal of pharmacology
- 2010
- 18
- PDF
Morphine-6-glucuronide is responsible for the analgesic effect after morphine administration: a quantitative review of morphine, morphine-6-glucuronide, and morphine-3-glucuronide.
- Medicine
- British journal of anaesthesia
- 2014
- 57
- PDF
Contribution of Morphine and Morphine-6-Glucuronide to Respiratory Depression in a Child
- Medicine
- Anaesthesia and intensive care
- 2012
- 12
Neuroexcitatory effects of morphine-3-glucuronide are dependent on Toll-like receptor 4 signaling
- Medicine
- Journal of Neuroinflammation
- 2012
- 78
References
SHOWING 1-10 OF 91 REFERENCES
Pharmacodynamic Effect of Morphine-6-glucuronide versus Morphine on Hypoxic and Hypercapnic Breathing in Healthy Volunteers
- Medicine
- Anesthesiology
- 2003
- 91
- PDF
Morphine-6-beta-D-glucuronide respiratory pharmacodynamics in the neonatal guinea pig.
- Medicine
- The Journal of pharmacology and experimental therapeutics
- 1994
- 27
Further evidence that morphine-6 beta-glucuronide is a more potent opioid agonist than morphine.
- Chemistry, Medicine
- The Journal of pharmacology and experimental therapeutics
- 1992
- 151
Respiratory depression following morphine and morphine-6-glucuronide in normal subjects.
- Medicine
- British journal of clinical pharmacology
- 1995
- 111
Analgesic efficacy and CSF pharmacokinetics of intrathecal morphine-6-glucuronide: comparison with morphine.
- Medicine
- British journal of anaesthesia
- 1990
- 124
Preemptive Intravenous Morphine-6-glucuronide Is Ineffective for Postoperative Pain Relief
- Medicine
- Anesthesiology
- 2000
- 45
Antinociceptive and ventilatory effects of the morphine metabolites: morphine-6-glucuronide and morphine-3-glucuronide.
- Medicine
- European journal of pharmacology
- 1991
- 173
Explanation at the opioid receptor level for differing toxicity of morphine and morphine 6-glucuronide.
- Chemistry, Medicine
- British journal of cancer
- 1992
- 41
- PDF