Morphine‐6‐glucuronide: Actions and mechanisms

  title={Morphine‐6‐glucuronide: Actions and mechanisms},
  author={Gavin Kilpatrick and T. Smith},
  journal={Medicinal Research Reviews},
  • Gavin Kilpatrick, T. Smith
  • Published 2005
  • Medicine
  • Medicinal Research Reviews
  • Morphine‐6‐glucuronide (M6G) appears to show equivalent analgesia to morphine but to have a superior side‐effect profile in terms of reduced liability to induce nausea and vomiting and respiratory depression. The purpose of this review is to examine the evidence behind this statement and to identify the possible reasons that may contribute to the profile of M6G. The vast majority of available data supports the notion that both M6G and morphine mediate their effects by activating the µ‐opioid… CONTINUE READING
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