Morphine, enkephalin and the substantia gelatinosa

@article{Duggan1976MorphineEA,
  title={Morphine, enkephalin and the substantia gelatinosa},
  author={Arthur W Duggan and Jens G. Hall and Patrick Headley},
  journal={Nature},
  year={1976},
  volume={264},
  pages={456-458}
}
THE pentapeptide enkephalin interacts with opiate receptors of peripheral tissues1 and with stereospecific opiate receptors of brain homogenates2. Ejected from micropipettes in the vicinity of central neurones, it has depressant3–5 and excitant6 effects. These actions, however, cannot be related specifically to the analgesic effects of systematically administered opiates. In electrophoretic experiments, tissue concentrations are unknown and hence even antagonism by electrophoretic naloxone is… CONTINUE READING